This is a working overview of GW501516, written for readers who want more than a one-paragraph summary but less than a textbook.
Reviewed 2026-06-15. Anything still debated is marked as such rather than presented as settled.
Clinical development stopped after rodent studies showed tumors at multiple sites. Whether those findings predict human cancer risk remains an open question, but they led sponsors to discontinue programs. Human safety data are limited to small, short-term studies that were not designed to assess cancer risk. Reported effects in those studies included changes in blood lipids, but the evidence is insufficient for medical use. Long-term consequences of nonmedical use are not well characterized. Questions about dose, duration, and individual susceptibility remain unresolved.
Cardarine is a common name for GW501516, an investigational compound developed in the 1990s for metabolic conditions. It acts as an agonist at peroxisome proliferator-activated receptor delta, a nuclear receptor involved in lipid and energy metabolism. The compound is frequently mislabeled as a selective androgen receptor modulator, or SARM, but its molecular target is different. GW501516 reached early clinical testing before development was discontinued. It has no approved therapeutic use in any country. The name cardarine is not a formal international nonproprietary name.
Regulatory treatment varies, but cardarine is not approved as a medicine. Sports authorities list GW501516 as a prohibited substance, and it is banned at all times under the World Anti-Doping Agency code. Many countries restrict sales for human consumption, while online vendors market it as a research chemical. Such products may lack purity data, and their actual contents can differ from the label. Purchasing or possessing cardarine may carry legal consequences depending on jurisdiction. The compound is not a dietary supplement ingredient in regulated markets.
In laboratory settings, cardarine is studied as a tool compound for probing PPARδ biology. Published experiments often use cell cultures, rodent models, or isolated tissues. Some investigations focus on metabolic effects, while others assess potential risks such as carcinogenicity observed in long-term animal studies. Because human trials are sparse, most knowledge comes from preclinical work and adverse event reports. Scientific literature frequently notes the gap between animal findings and human outcomes. The compound is not a dietary supplement and is not intended for human consumption.
Cardarine is a common name for GW501516, a synthetic compound developed in the 1990s through research collaborations involving GlaxoSmithKline. It belongs to a class of molecules known as peroxisome proliferator-activated receptor delta agonists. Early studies explored its effects on lipid metabolism and energy expenditure in animal models. The compound was never approved as a human medicine, and clinical development was discontinued. In the years since, it has appeared in fitness and bodybuilding communities as a performance-enhancing substance. Regulatory agencies classify it as an unapproved drug.
PPARδ is a nuclear receptor that regulates gene expression related to fatty acid oxidation, glucose homeostasis, and mitochondrial function. GW501516 binds to this receptor with high affinity and activates downstream signaling in skeletal muscle and other tissues. Animal studies reported increased endurance and altered fuel preference, but human data remain limited and inconsistent. The precise relationship between receptor activation and observed physiological changes is still an area of active investigation. Researchers have also examined whether the compound affects inflammation or cell proliferation. No approved therapeutic indication exists for cardarine.
| Property | Value | Notes |
|---|---|---|
| Common synonyms | GW501516; GW-1516; endurobol | GW501516 is the research code |
| Drug class | PPARδ agonist | Not a selective androgen receptor modulator |
| Molecular formula | C21H18F3NO3S2 | Established chemical formula |
| Molar mass | 453.5 g/mol | Calculated from the formula |
| Regulatory status | Prohibited in sport; not approved as medicine | Status varies by country |
Published literature on cardarine includes in vitro assays, rodent experiments, and a small number of human studies. Reports describe effects on exercise capacity and lipid metabolism in animals, while human evidence is sparse. Many online descriptions present the compound as a proven endurance aid, a claim not supported by regulatory approval or large clinical trials. Analytical studies focus on identifying the parent compound and its metabolites in biological samples. Important uncertainties include species differences, dose-response relationships, and the relevance of rodent tumor findings to humans.
Cardarine is the common name for GW501516, a synthetic compound studied as a peroxisome proliferator-activated receptor delta agonist. Researchers developed it to explore treatments for lipid disorders and metabolic conditions. It is not an approved medicine in any country. Early clinical work examined changes in HDL cholesterol and triglycerides, but development was discontinued after animal studies raised concerns about cancer. The compound remains available as a research chemical and appears in discussions of performance enhancement.
At the molecular level, GW501516 binds and activates PPARδ, a nuclear receptor that regulates transcription. Activation shifts expression of genes involved in fatty acid oxidation, energy expenditure, and lipid transport in skeletal muscle and liver. Animal studies report increased endurance and altered lipid profiles after exposure. Human data are limited to small trials and do not establish long-term safety or efficacy. PPARδ also has roles in cell proliferation, so the relationship between activation and cancer risk remains an open question.
Published studies have examined GW501516 in animal models of obesity, insulin resistance, and exercise endurance. Early human trials reportedly ended, and development was discontinued after preclinical findings raised concerns about cancer in some rodent studies. Regulatory agencies have not approved cardarine for any medical use. Its availability through non-pharmaceutical channels raises questions about identity, purity, and legal status that are separate from its laboratory pharmacology. Those questions are often addressed through analytical testing rather than assumptions about product labels.
Cardarine is a common name for GW501516, also GW-1516, a synthetic compound developed as a peroxisome proliferator-activated receptor delta (PPARδ) agonist. It belongs to a class of agents that modulate gene transcription related to lipid and energy metabolism. The compound was studied in preclinical and early clinical research for metabolic and cardiovascular conditions, but it did not progress to approved therapeutic use. Its name appears in fitness and sports contexts despite not being approved as a drug.
PPARδ is a nuclear receptor that influences transcription of genes involved in fatty acid oxidation, lipid transport, and energy homeostasis. GW501516 binds and activates this receptor with high selectivity relative to PPARα and PPARγ in laboratory assays. Activation alters expression of target genes in skeletal muscle, liver, and adipose tissue in animal models. The exact clinical consequences of these changes in humans remain incompletely characterized, and observed effects in animals do not establish therapeutic benefit or safety.
A key challenge for these approaches is a lack of widely accepted standards, and ambiguity about what the methods would require, as well as a lack of safety culture in the industry. Efforts to enhance AI safety include frameworks designed to align AI outputs with ethical guidelines and reduce risks like misuse and data leakage. Tools such as Nvidia's Guardrails, Llama Guard, Preamble's customizable guardrails, and Anthropic's "Claude's Constitution" mitigate vulnerabilities like prompt injection and ensure outputs adhere to predefined principles. These frameworks are often integrated into AI systems to improve safety and reliability.
==== Distribution ==== The drug is distributed widely throughout the body, including in saliva, bile, cerebrospinal fluid, synovial fluids, and pleural effusions. In accordance with its presence in cerebrospinal fluid, methenamine is known to cross the blood–brain barrier and enter the central nervous system. The volume of distribution and plasma protein binding of methenamine are unknown.
== External links == What is a WW domain? Ranganathan lecture on statistical coupling analysis (audio included) Protein folding — a step closer? - A summary of the Ranganathan lab's SCA-based design of artificial yet functional WW domains.
elegans this initiation response is amplified through the synthesis of a population of 'secondary' siRNAs during which the Dicer-produced initiating or 'primary' siRNAs are used as templates. These 'secondary' siRNAs are structurally distinct from Dicer-produced siRNAs and appear to be produced by an RNA-dependent RNA polymerase (RdRP).
Cardiolipin (IUPAC name 1,3-bis(sn-3’-phosphatidyl)-sn-glycerol, "sn" designating stereospecific numbering) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. It can also be found in the membranes of most bacteria. The name "cardiolipin" is derived from the fact that it was first found in animal hearts. It was first isolated from the beef heart in the early 1940s by Mary C. Pangborn. In mammalian cells, but also in plant cells, cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane, where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism.
Sources: en.wikipedia.org
== Overview == A sequence begins with a greater-than character (">") followed by a description of the sequence (all in a single line). The lines immediately following the description line are the sequence representation, with one letter per amino acid or nucleic acid, and are typically no more than 80 characters in length. For example:
The vagrant population of the Bowery declined after the 1970s, in part because of the city's effort to disperse it. Since the 1990s the entire Lower East Side has been reviving, and gentrification has contributed to ongoing change along the Bowery. In particular, the number of high-rise condominiums is growing. In 2007, the SANAA-designed facility for the New Museum of Contemporary Art opened between Stanton and Prince Street. In 2008, AvalonBay Communities opened Avalon Bowery Place, its first luxury apartment complex on the Bowery; the structure includes a Whole Foods Market. Avalon Bowery Place was quickly followed with the development of Avalon Bowery Place II. The new development has not come without social costs. Michael Dominic's 2001 documentary Sunshine Hotel followed the lives of residents of one of the few remaining flophouses. Construction on the Wyndham Garden Hotel at 93 Bowery in the late Aughts destabilized neighboring building 128 Hester Street (owned by the same man, William Su), and 60 tenants were thrown out of the building with the help of the Department of Buildings. At least 75 tenants were displaced from 83 to 85 Bowery in January 2018 in frigid temperatures due to long-overdue repairs that needed to be made. Tenants accused the landlord of using this displacement to start renovating the buildings into a hotel, and they went on a hunger strike. The Bowery from Houston to Delancey Street still serves as New York's principal market for restaurant equipment and from Delancey to Grand for lamps.
=== Sodium ion channels === Sodium channels were the first voltage-gated ion channels to be isolated in 1984 from the eel Electrophorus electricus by Shosaku Numa. The pufferfish toxin tetrodotoxin (TTX), a sodium channel blocker, was used to isolate the sodium channel protein by binding it using the column chromatography technique for chemical separation. The amino acid sequence of the protein was analyzed by Edman degradation and then used to construct a cDNA library which could be used to clone the channel protein. Cloning the channel itself allowed for applications such as identifying the same channels in other animals. Sodium channels are known for working in concert with potassium channels during the development of graded potentials and action potentials. Sodium channels allow an influx of Na+ ions into a neuron, resulting in a depolarization from the resting membrane potential of a neuron to lead to a graded potential or action potential, depending on the degree of depolarization.
(2002) subsequently confirmed the same model for hydrogen adsorption on magnesia-supported caesium-ruthenium bimetallic catalysts. Trens et al. (2009) have similarly described CO surface diffusion on carbon-supported Pt particles of varying morphology.
== See also == List of University of California, Berkeley faculty List of University of California, Berkeley alumni in business and entrepreneurship List of University of California, Berkeley alumni in science and technology
Sources: en.wikipedia.org
== National poll results == Most opinion polls do not cover Northern Ireland, which has different major political parties from the rest of the United Kingdom. In the 'area' column of the tables below, "GB" (Great Britain) denotes polls that do not include Northern Ireland, whereas "UK" (United Kingdom) denotes polls that do. Plaid Cymru only stands candidates in Wales, the Scottish National Party only stands candidates in Scotland, and the Conservative Party is the only party with its own column below that stands candidates in Northern Ireland. Due to rounding, total figures may not add up to 100%. The lead is calculated by subtracting the polling percentage of the first-placed party by that of the second-placed party. The first-placed party is shaded with its party colour, and in boldface; the second-placed party is shaded in grey. The table can be sorted by all features; to sort by party vote share, click on the coloured ribbons. Where polls specify parties within 'other', this may be expandable by pressing the [show] button in the 'other' cell.
Pierre, et de Beatrix de Guine (1738 - English translation: Stories of the Earl of Oxford, of Milady of Herby, of Eustace of St. Peter, and of Beatrix of Guinea) La jeune Alcidiane (1733 - English translation: The Young Alcidiane) Les journées amusantes, dédiées au roi (1722 - English translation by Eliza Haywood: La Belle Assemblée published 1724–1734)
==== Strategies for EPS yield-increase ==== Although the EPS from microalgae have many potential applications, their low yield is one of the major limitations for scale-up in industry. The type and amount of EPS obtained from a certain microalgae-culture depends on several factors, such as culture system design, nutritional and culture conditions, as well as the recovery and purification process. Therefore, the configuration and optimization of production systems are critical for the further development of applications. Examples of successful increase of EPS yield include
=== Kla Tham Party === Deputy Prime Minister Thamanat Prompow first noted that the results exceeded expectations, especially in northern Thailand. He remained confident that the party would surpass more than 50 seats, emphasizing how the ministers and candidates of the Kla Tham Party were actively working in their respective constituencies throughout the campaign. Thamanat remarked that the party was still waiting for an invitation from Bhumjaithai to renew their past coalition. The party finished with 58 seats, ahead of his forecast, but no invitation came and Kla Tham was left out of the government.
A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7) is an enzyme that in humans is encoded by the ADAMTS7 gene on chromosome 15. It is ubiquitously expressed in many tissues and cell types. This enzyme was historically reported to catalyze the degradation of cartilage oligomeric matrix protein (COMP), though subsequent studies using purified proteins and unbiased mass spectrometry found that ADAMTS7 does not cleave COMP. ADAMTS7 has been associated with cancer and arthritis in multiple tissue types. The ADAMTS7 gene is a well-established genetic susceptibility locus for coronary artery disease. The ADAMTS7 gene resides on chromosome 15 at the band 15q24.2 and contains 25 exons.
Sources: en.wikipedia.org
No. Cardarine is GW501516, a PPARδ agonist, while SARMs act on androgen receptors. The two classes are often grouped in informal discussions despite different mechanisms.
No. It has no approved medical indication in any country. Regulatory agencies have not cleared it for treatment or prevention of any condition.
Early clinical work stopped after rodent carcinogenicity findings. Those animal results raised concerns about long-term human risk, although direct human evidence is lacking. The human relevance of the tumors remains an open scientific question.
Cardarine is a common name for GW501516, a synthetic PPARδ agonist developed for research. It has not been approved as a medication in any country. It is classified as an unapproved drug and a prohibited substance in sport.